Not exactly a workshop project, but my wife dropped a bottle of bright red enamel polish on the living room hardwood floor, and asked me to fix it. My first instinct was to grab the pure acetone from the garage.
Do not do this.
Acetone will absolutely dissolve the nail polish, but it will also strip the polyurethane clear coat right off your hardwood floor, leaving a dull, ruined patch that requires sanding and refinishing.
Instead, you need a method that lifts the polish without eating into the wood finish. Non-acetone removers, isopropyl alcohol, and sometimes just a bit of sugar (if the spill is fresh) can work wonders. For carpets, the approach is completely different and requires blotting, not rubbing. I pulled a lot of my strategy from this detailed breakdown on how to remove nail polish safely from various household surfaces.
Crisis averted. Floor is saved.